Have you ever wondered how the chirality of minuscule cellular components is manifest at the cell- or organism level? Adhham and Jenna found that the septins are required for the cortical rotation that occurs with consistent handedness, in early anaphase in the C. elegans zygote. While the septins are required for rotation to occur at all, the formin CYK-1 is required for the consistency of handedness and persistence of cortical flow. Check it out on BioRxiv and look out for it in a favorite journal soon!